Browse Articles

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Stereolithography 3D-printed stents with silica and zirconia nanoparticle reinforcement for intracranial aneurysm treatment

Panda et al. | Oct 12, 2026

Stereolithography 3D-printed stents with silica and zirconia nanoparticle reinforcement for intracranial aneurysm treatment
Image credit: Panda, Jeong, and Srinivasan

This manuscript focuses on improving the mechanical strength and radiopacity of SLA 3D-printed stent materials by incorporating nanoparticles for their application in flow-diverting stents (FDSs) used to treat aneurysms. The authors used biocompatible, bioresorbable resin formulations with varying concentrations of silica and zirconium to enhance tensile strength and radiopacity, respectively. The authors employed SEM to confirm the incorporation of nanoparticles, and CT imaging was used to assess the effect of zirconium-infused FDSs.

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