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Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

Velu et al. | Sep 26, 2026

Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

This study used multi-omic analysis to investigate gene expression and DNA methylation patterns associated with hypertrophic cardiomyopathy (HCM). The researchers found significant downregulation of mitochondrial and energy-related pathways, highlighting mitochondrial dysfunction—particularly altered PINK1 expression—as a potential contributor and therapeutic target in HCM.

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Mining social media posts: An alternative approach to understanding home health care workers’ experiences

Tang et al. | Jun 15, 2026

Mining social media posts: An alternative approach to understanding home health care workers’ experiences
Image credit: Markus Winkler

This study developed an effective method for extracting valuable information from social media data and employed computer-assisted human coding alongside the AI-powered tool to analyze social media posts. The findings provide a deep understanding of the major challenges that home health care workers are experiencing and offer important implications regarding how to improve home healthcare workers' well-being, and provide suggestions on optimizing the home health care service experience.

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