The authors examined the impact of mutations to CDK2 on protein expression.
Read More...Investigating the effects of mutations of amino acids on the protein expression of CDK2 cancer gene
Changing electronic use behavior in adolescents while studying: An interventional psychology experiment
Here, the authors investigated the effects of an interventional psychology on the study habits of high school students specifically related to the use of electronic distractions such as social media or texting, listening to music, or watching TV. They reported varying degrees of success between the control and intervention groups, suggesting that the methods of habit-breaking for students merits further study.
Read More...Floor level estimation using MEMS pressure sensors
The authors propose a method to help first responders find the location of a person within a high-rise building in densely populated areas.
Read More...Observing effects of resolving leaky gut on sugar, fat, and insulin levels during type 1 diabetes in fruit flies
This study uses a fruit fly model of type 1 diabetes (T1D) to determine whether strengthening intestinal tight junctions to reduce intestinal permeability would improve T1D symptoms.
Read More...Leaky expression of PRMT1 in Escherichia coli and redox regulation of its histone methyltransferase activity
This study characterizes recombinant human Protein arginine methyltransferase 1 (PRMT1) expressed in Escherichia. coli and reveals that the enzyme exhibits leaky expression even without isopropyl β-D-1-thiogalactopyranoside (IPTG) induction. Through in vitro histone methyltransferase assays, we demonstrate that PRMT1 activity toward histone H4R3 is enhanced by dithiothreitol (DTT) in a dose-dependent manner but remains unresponsive to β-mercaptoethanol. These findings highlight the critical role of redox conditions in regulating PRMT1 catalytic function and provide a practical framework for future biochemical and kinetic studies.
Evaluation of hepatotoxicity from excessive acetaminophen: physiological and histological changes
The authors looked at how acetaminophen may cause liver damage by looking at both serum level markers of liver damage as well as liver pathology.
Read More...CDK7 inhibition disrupts androgen signaling and induces metabolic rewiring in prostate cancer cells
The authors used RNA-seq datasets to assess the effect of CDK7 inhibition on transcriptional pathways in castration-resistant prostate cancer cells.
Read More...The effects of dysregulated ion channels and vasoconstriction in glioblastoma multiforme
Impact of TCERG1 SNP on gene expression and protein interactome in Huntington’s disease
The authors assess a genetic variant within a well-known interaction partner of huntingtin that has been linked to modifying the age of onset of Huntington's disease.
Read More...Incorporating graphite from pencils as a component of lithium-ion batteries
The authors looked at the ability to use graphite from pencils in anodes of lithium-anode batteries.
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