Browse Articles

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

Galaxy clusters offer several advantages for measuring H₀ compared to traditional methods, such as Cepheid variables or Type Ia supernovae. Unlike individual stars or supernovae, clusters are less affected by local variations in stellar population or interstellar medium properties, providing a more stable and consistent measure over large cosmological distances. This work proposes using galaxy clusters as an alternative method for determining the H₀. It provides an independent perspective on the H₀ debate and contribute to ongoing efforts to reconcile the differing values obtained from the other two measurements.

Machine learning systems are often expected to make fair decisions, yet the most widely used fairness criteria—independence, separation, and sufficiency—cannot generally be satisfied at the same time. In this study, students tested these criteria using a logistic regression model on a real-world student performance dataset and found that each criterion was met only at different prediction thresholds, with no threshold satisfying all three simultaneously. These results illustrate the inherent trade-offs in algorithmic fairness and highlight why achieving perfectly fair machine learning models is often impossible in practice.

In this study, the authors examine the relationship between ESG (Environmental, Social, and Governance) factors on financial performance of Vietnamese media companies, as measured by ROA and ROE. They find that ESG is positively correlated with financial performance, as is sales growth. They also find that financial leverage is negatively correlated with ROA. Overall, this is a quality study, although the methods section requires more detail.

This article investigates whether induction heating can speed up static recrystallization in AISI 4130 steel compared with traditional radiant heating. It was found that induction-heated samples recrystallized faster, softened more quickly, and showed earlier microstructural changes like grain nucleation and pearlite spheroidization, suggesting induction heating could be a more efficient alternative for industrial metal heat treatments.

This study examined how social determinants of health (SDH) relate to vision loss by analyzing publicly available data from 18 northern and southern U.S. states and using Bayesian correlation analysis.

Lung cancer is highly fatal, largely due to late diagnoses, but early detection can greatly improve survival. This study developed three models to enhance early diagnosis: an MLP for clinical data, a CNN for imaging data, and a hybrid model combining both.

Black patients tend to have better health outcomes when cared for by Black physicians, yet Black doctors make up only 5% of U.S. physicians, despite Black people comprising 14% of the population. This analysis of data from Florida medical schools showed a higher enrollment of Black first-year students (13.5%) compared to the national average (9%), and a national increase from 6% in 2013 to 9% in 2021, aligning with the rise of social justice movements. Increasing Black medical student enrollment could reduce health disparities and improve outcomes for Black communities.

The authors looked at how molarity impacts the degree to which ionic compounds dissociate in solution. They found that lower molarities led to decreased conductivity of solutions in a manner that did not follow the theoretical predictions.

In the age of global warming, these authors studied which of the four major greenhouse gases (water vapor, carbon dioxide, and nitrous oxide) change the most with increased temperature.