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Potential Multifunctional Agents for Dual Therapy of Age-Related and Associated Diseases: Alzheimer’s Disease and Type 2 Diabetes Mellitus

Kumar et al. | Nov 13, 2019

Potential Multifunctional Agents for Dual Therapy of Age-Related and Associated Diseases: Alzheimer’s Disease and Type 2 Diabetes Mellitus

Studies show an age-related link between Alzheimer’s Disease and Type 2 Diabetes Mellitus with oxidative stress a characteristic of both. Here, methanolic fractionations and extracts of four Ayurvedic plants were assessed for their protective abilities using a number of in vitro assays. Extracts inhibited oxidative stress and reduced activity of key enzymes involved in the pathogenesis of both diseases in neuroblastoma cells.

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Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Jang et al. | Aug 19, 2016

Peptidomimetics Targeting the Polo-box Domain of Polo-like Kinase 1

Polo-like kinase 1 (Plk1) is a master regulator of mitosis, initiating key steps of cell cycle regulation, and its overexpression is associated with certain types of cancer. In this study, the authors carefully designed peptides that were able to bind to Plk1 at a location that is important for its proper localization and function. Future studies could further develop these peptides to selectively target Plk1 in cancer cells and induce mitotic arrest.

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Investigating the effects of PVC microplastics on the growth of Chlorella vulgaris

Beaubien et al. | Oct 13, 2026

Investigating the effects of PVC microplastics on the growth of <i>Chlorella vulgaris</i>

This study examined the effect of varying PVC microplastic concentrations on the growth of Chlorella vulgaris in freshwater, utilizing six PVC levels and identical culture conditions. Cell counts revealed that higher PVC concentrations consistently reduced algal growth, and a Spearman correlation test detected a significant negative monotonic association between PVC concentration and viable cell density. These results support the hypothesis that PVC microplastics impair algal growth, underscoring their ecological risk in freshwater environments.

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