Browse Articles

This study combines gene expression, mutation profiling, and survival analysis of 17 clinically important genes in breast cancer, utilizing the TCGA-BRCA dataset. Our results show that there are different patterns of oncogene upregulation, different levels of tumor suppressor activity, and complicated survival associations. TP53 was the most frequently mutated gene in this cohort. The results underscore the significance of multidimensional genomic analyses for a comprehensive understanding of breast cancer biology and its therapeutic ramifications.

The authors assess a genetic variant within a well-known interaction partner of huntingtin that has been linked to modifying the age of onset of Huntington's disease.

This article describes the classification of medical text data using vector databases and text embedding. Various large language models were used to generate this medical data for the classification task.

In 2021, over 20 million people died from cardiovascular diseases, highlighting the need for a deeper understanding of factors influencing heart failure outcomes. This study examined multiple variables affecting mortality after heart failure, using random forest models to identify time, serum creatinine, and ejection fraction as key predictors. These findings could contribute to personalized medicine, improving survival rates by tailoring treatment strategies for heart failure patients.

The authors surveyed individuals diagnosed with coronary artery disease about their mental health to study a potential connection between coronary artery disease and depression.

The study discusses the relationship between bacterial species and the human gut microbiome, emphasizing the role of quorum sensing molecules in bacterial communication and its implications for health. Authors investigated the impact of bacterial supernatants from Escherichia coli (E. coli) on the growth of new E. coli and Enterobacter aerogenes (E. aerogenes) cultures.

Here, seeking to better understand the genetic associations underlying non-small cell lung cancer, the authors screened hundreds of genes, identifying that KCNMB2 upregulation was significantly correlated with poor prognoses in lung cancer patients. Based on this, they used small interfering RNA to decrease the expression of KCNMB2 in A549 lung cancer cells, finding decreased cell proliferation and increased lung cancer cell death. They suggest this could lead to a new potential target for lung cancer therapies.

In this study, the authors investigate associations between use of histamine H₂ receptor antagonists and suicidal ideation in different age groups.

The diagnosis of malaria remains one of the major hurdles to eradicating the disease, especially among poorer populations. Here, the authors use machine learning to improve the accuracy of deep learning algorithms that automate the diagnosis of malaria using images of blood smears from patients, which could make diagnosis easier and faster for many.

In this study, the authors studied the ability for bacteria to develop antibiotic resistance over successive generations and modeled the trajectory to predict how antibiotic resistance is developed.