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Stereolithography 3D-printed stents with silica and zirconia nanoparticle reinforcement for intracranial aneurysm treatment

Panda et al. | Oct 12, 2026

Stereolithography 3D-printed stents with silica and zirconia nanoparticle reinforcement for intracranial aneurysm treatment
Image credit: Panda, Jeong, and Srinivasan

This manuscript focuses on improving the mechanical strength and radiopacity of SLA 3D-printed stent materials by incorporating nanoparticles for their application in flow-diverting stents (FDSs) used to treat aneurysms. The authors used biocompatible, bioresorbable resin formulations with varying concentrations of silica and zirconium to enhance tensile strength and radiopacity, respectively. The authors employed SEM to confirm the incorporation of nanoparticles, and CT imaging was used to assess the effect of zirconium-infused FDSs.

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Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

Velu et al. | Sep 26, 2026

Multi-omic analysis identifies mitochondrial dysfunction as a key feature of hypertrophic cardiomyopathy

This study used multi-omic analysis to investigate gene expression and DNA methylation patterns associated with hypertrophic cardiomyopathy (HCM). The researchers found significant downregulation of mitochondrial and energy-related pathways, highlighting mitochondrial dysfunction—particularly altered PINK1 expression—as a potential contributor and therapeutic target in HCM.

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An analysis of the mechanical properties of fencing swords, and implications for weapon selection

Redmond et al. | Aug 24, 2026

An analysis of the mechanical properties of fencing swords, and implications for weapon selection
Image credit: Jonathan Falcon

The sword is the most important piece of equipment a fencer uses. In this study, we compared the mechanical and physical properties of two of the most common types of swords used in foil fencing.We that found that maraging steel blades had a significantly greater stiffness and were damped more effectively than low carbon steel blades. These properties affect how the blade behaves during particular maneuvers and techniques, and our findings therefore provide useful insights for fencers who want to select the optimal sword configuration to suit their personal style.

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The analysis of the viral transmission and structural interactions between the HIV-1 envelope glycoprotein and the lymphocyte receptor integrin α4β7

Ganesh et al. | Apr 28, 2021

The analysis of the viral transmission and structural interactions between the HIV-1 envelope glycoprotein and the lymphocyte receptor integrin α4β7

The Human Immunodeficiency Virus (HIV) infects approximately 40 million people globally, and one million people die every year from Acquired Immune Deficiency Syndrome (AIDS)-related illnesses. This study examined the interactions between the HIV-1 envelope glycoprotein gp120 and the human lymphocyte receptor integrin α4β7, the putative first long-range receptor for the envelope glycoprotein of the virus in mucosal tissues. Presented data support the claim that the V1 loop is involved in the binding between α4β7 and the HIV-1 envelope glycoprotein through molecular dockings.

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Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Sun et al. | Dec 18, 2020

Computational Structure-Activity Relationship (SAR) of Berberine Analogs in Double-Stranded and G-Quadruplex DNA Binding Reveals Both Position and Target Dependence

Berberine, a natural product alkaloid, and its analogs have a wide range of medicinal properties, including antibacterial and anticancer effects. Here, the authors explored a library of alkyl or aryl berberine analogs to probe binding to double-stranded and G-quadruplex DNA. They determined that the nature of the substituent, the position of the substituent, and the nucleic acid target affect the free energy of binding of berberine analogs to DNA and G-quadruplex DNA, however berberine analogs did not result in net stabilization of G-quadruplex DNA.

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