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This study compares traditional and discovery-based instructional methods in online middle school mathematics education. Findings show that discovery-based learning significantly improves students’ academic performance and attitudes, highlighting the value of inquiry-driven instruction for enhancing both understanding and motivation.

This manuscript tackles a major social issue in the health news sector, with social media being one of the primary sources of information and a prime spot to propagate fake news. The author proposes X-HND , which is a unique architecture that combines emotional and contextual analysis in a Graph Neural Network to accurately detect fake news. This was a multi-step process which involved the creation of a custom health news dataset (HNDataset), and an emotional variant that uses RoBERTa to extract emotion. These dataset were then used to prove the hypothesis that accuracy increases when the custom dataset is used to train the model and that with the integration of emotion capture, the detection accuracy increases further.

Elevated acetylcholinesterase (AChE) activity contributes to cognitive decline and neurodegenerative diseases such as Alzheimer’s, motivating the search for more effective inhibitors with better bioavailability. This study used computational methods to design novel, non-toxic AChE inhibitors.

The authors employ computational protein design to identify a mini-protein with the potential to enhance binding of the tight junction protein, claudin-5, at the blood-blood barrier with therapeutic potential for neurodegenerative diseases.

This study examined the impact of erosion on the performance of a triangular aerofoil at a low Reynolds number (Re = 10,000), relevant for harsh conditions like those on Mars.

Here, recognizing that brain aneurysms pose a severe threat, often misdiagnosed and leading to high mortality, particularly in younger individuals, the authors explored a novel computer-aided engineering approach. They used magnetic resonance angiography images and computational fluid dynamics, to improve aneurysm detection and risk assessment, aiming for more personalized treatment.

The authors looked at potential downstream effects of raising the minimum wage. Specifically they focused on taxable wages, employment, and firm counts.

The authors test different machine learning algorithms to remove background noise from audio to help people with hearing loss differentiate between important sounds and distracting noise.

In this study, a deep learning model is used to classify post-traumatic stress disorder patients through novel markers to assist in finding candidate biomarkers for the disorder.

Naturally occurring neuroactive alkaloids are often studied for their potential to treat Neurological diseases. This team of students study Rivastigmine, a potent cholinesterase inhibitor that is a synthetic analog of physostigmine, which comes from the Calabar bean plant Physostigma venenosum. By comparing the effects of optimized synthetic analogs to the naturally occurring alkaloid, they determine the most favorable analog for inhibition of acetylcholinesterase (AChE), the enzyme that breaks down the neurotransmitter acetylcholine (ACh) to terminate neuronal transmission and signaling between synapses.