Browse Articles

This study explores the interaction between precocene II and trichocethecene 3-O-acetyltransferase using molecular docking simulations. Computational analysis identified several potential binding sites on the enzyme surface and predicted favorable ligand-protein interactions involving key residues. These findings provide insight into how precocene II may interact with this enzyme and demonstrate the use of computational approaches to explore potential antifungal mechanisms.

This study evaluates the potential of natural language processing (NLP) models in an emotion-driven bibliotherapy framework to improve mental health challenges.

The authors looked at the feasibility to predict wind speeds that will have less reliance on using historical data.

This study investigates the effects of the PROTAC compound A1874 on CT26 colon carcinoma cells, focusing on its ability to degrade the protein BRD4 and reduce cell viability. While A1874 had previously shown effectiveness in other colon cancer cell lines, its impact on CT26 cells was unknown.

The authors looked at hydrogen gas production and how reaction temperature, concentration and alkaline solution used impacted the overall reaction with silicon. They found that all alkaline solutions tested would be viable options for using silicon waste to produce hydrogen gas to be used a renewable energy source.

The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.

Glioblastoma Multiforme (GBM) is the most malignant brain tumor with the highest fraction of genome alterations (FGA), manifesting poor disease-free status (DFS) and overall survival (OS). We explored The Cancer Genome Atlas (TCGA) and cBioportal public dataset- Firehose legacy GBM to study DNA repair genes Activating Signal Cointegrator 1 Complex Subunit 3 (ASCC3) and Alpha-Ketoglutarate-Dependent Dioxygenase AlkB Homolog 3 (ALKBH3). To test our hypothesis that these genes have correlations with FGA and can better determine prognosis and survival, we sorted the dataset to arrive at 254 patients. Analyzing using RStudio, both ASCC3 and ALKBH3 demonstrated hypomethylation in 82.3% and 61.8% of patients, respectively. Interestingly, low mRNA expression was observed in both these genes. We further conducted correlation tests between both methylation and mRNA expression of these genes with FGA. ASCC3 was found to be negatively correlated, while ALKBH3 was found to be positively correlated, potentially indicating contrasting dysregulation of these two genes. Prognostic analysis showed the following: ASCC3 hypomethylation is significant with DFS and high ASCC3 mRNA expression to be significant with OS, demonstrating ASCC3’s potential as disease prediction marker.

Here the authors investigate the potential of the bioluminescent fungus Panellus stipticus to serve as a sustainable bioindicator for environmental lead contamination. Their findings demonstrate that higher lead concentrations cause a measurable decrease in fungal bioluminescence intensity over time suggesting that the fungus could be an effective tool for detecting lead in an environment.

This study investigates how the hyperparameters epochs and batch size affect the classification accuracy of a convolutional neural network (CNN) trained on pulsar candidate data. Our results reveal that accuracy improves with increasing number of epochs and smaller batch sizes, suggesting that with optimized hyperparameters, high accuracy may be achievable with minimal training. These findings offer insights that could help create more efficient machine learning classification models for pulsar signal detection, with the potential of accelerating pulsar discovery and advancing astrophysical research.

The authors design and test an easy-to-use and cost-effective mobile app-based alert system to help senior citizens rapidly communicate with caregivers in emergencies or when in need of assistance.