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Investigating the Role of the Novel ESCRT-III Recruitment Factor CCDC11 in HIV Budding: A Potential Target for Antiviral Therapy

Takemaru et al. | Feb 24, 2020

Investigating the Role of the Novel ESCRT-III Recruitment Factor CCDC11 in HIV Budding: A Potential Target for Antiviral Therapy

Acquired immunodeficiency syndrome (AIDS) is a life-threatening condition caused by the human immunodeficiency virus (HIV). In this work, Takemaru et al explored the role of Coiled-Coil Domain-Containing 11 (CCDC11) in HIV-1 budding. Their results suggest that CCDC11 is critical for efficient HIV-1 budding, potentially indicating CCDC11 a viable target for antiviral therapeutics without major side effects.

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An in silico molecular analysis of the antifungal properties of Ageratum conyzoides

Sathish et al. | Apr 28, 2026

An <i>in silico</i> molecular analysis of the antifungal properties of <i>Ageratum conyzoides</i>
Image credit: Bánh Bao Chiên

This study explores the interaction between precocene II and trichocethecene 3-O-acetyltransferase using molecular docking simulations. Computational analysis identified several potential binding sites on the enzyme surface and predicted favorable ligand-protein interactions involving key residues. These findings provide insight into how precocene II may interact with this enzyme and demonstrate the use of computational approaches to explore potential antifungal mechanisms.

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Paralyzing effects of CO2 and hypothermia on Madagascar hissing and dubia cockroaches

Gapon et al. | Dec 08, 2024

Paralyzing effects of CO<sub>2</sub> and hypothermia on Madagascar hissing and dubia cockroaches
Image credit: Jesper Aggergaard

Here the authors sought to find a more ethical and efficient way to temporary paralyze a cockroach by comparing the results of two methods. By comparing immobilization through immersion in cold water and exposure to a 100 % CO2 environment, they found that cockroaches could be immobilized and recovered significantly faster when exposed to CO2.

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