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Irrespective of the final application of a molecule, synthetic accessibility is the rate-determining step in discovering and developing novel entities. However, synthetic complexity is challenging to quantify as a single metric, since it is a composite of several measurable metrics, some of which include cost, safety, and availability. Moreover, defining a single synthetic accessibility metric for both natural products and non-natural products poses yet another challenge given the structural distinctions between these two classes of compounds. Here, we propose a model for synthetic accessibility of all chemical compounds, inspired by the Central Limit Theorem, and devise a novel synthetic accessibility metric assessing the overall feasibility of making chemical compounds that has been fitted to a Gaussian distribution.

The authors investigate whether human blood cancers carrying mutations in DNA repair genes possess increased sensitivity to common chemotherapy drugs cisplatin or gemcitabine.

Here the authors used a free radical assay to characterize the antioxidant capacity of three types of coffee beans. They fond that Robusta coffee presented greater inhibition percentages than other species in their free radical assay, indicating higher antioxidant capacity.

The authors test the durability of synthetic versus non-synthetic fabrics though loose thread counts, color fade over time, and shrinkage tests.

This study aimed to combat widespread hydrocarbon residue persistently polluting global water sources by developing and testing the ability of modified iron(III) oxide-hydroxide (FeO(OH)) nanoparticles to remove small amounts of motor oil from freshwater

The authors looked at energy efficient ways to generate small nitrogenous compounds.

In this study, the authors conduct a bibliometric analysis to understand the recent growth in and current state of peripheral nerve regeneration research. They also explored potential future studies.

The use of fertilizers is associated with an increase in soil degradation, which is predicted to lead to a decrease in crop production within the next decade. Thus, it is critical to find solutions to support crop production to sustain the robust global population. In this study, the authors investigate how probiotic bacteria, like Rhizobium leguminosarum, Bacillus subtilis and Pseudomonas fluorescens, can impact the growth of Arabidopsis thaliana when applied to the seeds.They hypothesized that solutions with multiple bacterial species compared to those with only a single bacterial species would promote seed germination more effectively.

This study explores global trends in average total cholesterol levels among adults from 1980 to 2018, finding a significant decline in both men and women, with a sharper decrease among men. While these improvements likely reflect advances in public health and medical treatment, the persistent gender gap highlights the need for more targeted approaches to cardiovascular disease prevention.

Since school bathrooms are widely suspected to be unsanitary, we wanted to compare the total amount of bacteria with the amount of bacteria that had ampicillin or streptomycin resistance across different school bathrooms in the Boston area. We hypothesized that because people interact with the faucet, outdoor handle, and indoor handle of the bathroom, based on whether or not they have washed their hands, there would be differences in the quantity of the bacteria presented on these surfaces. Therefore, we predicted certain surfaces of the bathroom would be less sanitary than others.